KapanLagi.com - Researchers have found the instructions on the new AIDS drugs that are widely used have certain side effects such as hoarding of fat is mysterious.
Parallel between the protease inhibitors side effects (an important component in the mixture of HIV drugs) and genetic conditions that lead to early penuaan may help explain the precipitation of fat that often make the patient weak and the results of others. Protease inhibitors can cause metabolic disturbances, such as hoarding is not healthy cholesterol in the blood, high blood pressure, and increased risk of diabetes.
Substances also trigger the condition, called lipodystrophy, which is a strange redistribution of fat and cheek so that other members of the patient's body buried fat, the fat and buffalo hump on the back and nape.
Doctors have long wondered about how protease inhibitors and other HIV medications can cause side effects such as these, which occur on the tens of thousands of drug users in the world, said Dr. Charles Flexner from John Hopkins University School of Medicine.
In an effort to reveal the condition, one group of scientists from the University of California Los Angeles and Purdue University in Indiana to use protease inhibitors in mouse and human cells, and found that the oxygen precipitate in the form of a special protein called a cloud of prelamin A.
Drugs that trigger the condition impede the movement of other proteins (ZMPSTE24), which change the form of prelamin A to be useful, as they report in Proceedings of the National Academy of Sciences.
Cells, the level of ZMPSTE24 to be lower when the patients began using protease inhibitors.
Christine Hrycyna from Purdue University, involved in the study, said terhalangnya protein that may give a donation for the metabolic side effects of protease inhibitors.
Penuaan patients with early symptoms, including Hutchinson-Gilford progeria, have symptoms that resemble side effects, and buried the same protein in their cells, said Hrycyna. However not clear how it can affect the metabolism, he said.
"This side effect might not only caused by only one simple condition," said Hrycyna.
"I think this script may provide new insights about the mechanisms that may be part of the side effects of protease inhibitors," says Flexner.
The researchers will also try to test some other drugs commonly used in a mixture of AIDS drugs, known as the anti-retrovirus therapy which is very active, or HAART. But not other drugs cause the same storehouse of protein, even though the drugs may cause similar effects in people, said the researchers.
"That all may be caused by a combination of all these different drugs," said Hrycyna.
The researchers now want to see if they have a theory of truth in HIV patients, and if different versions of protease inhibitors that do not impede the ZMPSTE24, may cause side effects that are fewer in all the patients. (* / cax)
Parallel between the protease inhibitors side effects (an important component in the mixture of HIV drugs) and genetic conditions that lead to early penuaan may help explain the precipitation of fat that often make the patient weak and the results of others. Protease inhibitors can cause metabolic disturbances, such as hoarding is not healthy cholesterol in the blood, high blood pressure, and increased risk of diabetes.
Substances also trigger the condition, called lipodystrophy, which is a strange redistribution of fat and cheek so that other members of the patient's body buried fat, the fat and buffalo hump on the back and nape.
Doctors have long wondered about how protease inhibitors and other HIV medications can cause side effects such as these, which occur on the tens of thousands of drug users in the world, said Dr. Charles Flexner from John Hopkins University School of Medicine.
In an effort to reveal the condition, one group of scientists from the University of California Los Angeles and Purdue University in Indiana to use protease inhibitors in mouse and human cells, and found that the oxygen precipitate in the form of a special protein called a cloud of prelamin A.
Drugs that trigger the condition impede the movement of other proteins (ZMPSTE24), which change the form of prelamin A to be useful, as they report in Proceedings of the National Academy of Sciences.
Cells, the level of ZMPSTE24 to be lower when the patients began using protease inhibitors.
Christine Hrycyna from Purdue University, involved in the study, said terhalangnya protein that may give a donation for the metabolic side effects of protease inhibitors.
Penuaan patients with early symptoms, including Hutchinson-Gilford progeria, have symptoms that resemble side effects, and buried the same protein in their cells, said Hrycyna. However not clear how it can affect the metabolism, he said.
"This side effect might not only caused by only one simple condition," said Hrycyna.
"I think this script may provide new insights about the mechanisms that may be part of the side effects of protease inhibitors," says Flexner.
The researchers will also try to test some other drugs commonly used in a mixture of AIDS drugs, known as the anti-retrovirus therapy which is very active, or HAART. But not other drugs cause the same storehouse of protein, even though the drugs may cause similar effects in people, said the researchers.
"That all may be caused by a combination of all these different drugs," said Hrycyna.
The researchers now want to see if they have a theory of truth in HIV patients, and if different versions of protease inhibitors that do not impede the ZMPSTE24, may cause side effects that are fewer in all the patients. (* / cax)
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